Thymoquinone > Cortisol

Thymoquine & Cortisol

Research on thymoquinone, the active compound in black cumin seed oil, has highlighted its potential in managing cortisol levels and supporting overall stress response. Studies indicate that thymoquinone may help modulate the body’s stress response, reduce oxidative stress, and improve overall well-being.

Key Findings
  • Cortisol Reduction in Stress Models: Thymoquinone has been shown to lower elevated cortisol levels in animal models subjected to chronic stress, suggesting potential benefits in moderating the body’s stress response and protecting against stress-related damage.
  • Anti-Inflammatory and Antioxidant Effects: Research by Dr. Shawn Talbott demonstrated that black seed oil’s anti-inflammatory properties could help regulate cortisol production by decreasing systemic inflammation and oxidative stress, which are known to disrupt normal adrenal function.
  • Impact on Cortisol-Related Metabolic Disorders: In clinical trials, supplementation with black seed oil improved metabolic parameters (such as blood glucose and lipid profiles) and reduced cortisol levels in patients with metabolic syndrome. These findings suggest a possible link between black seed oil supplementation and improved stress hormone balance.
  • Potential Adaptogenic Properties: Black seed oil has demonstrated adaptogenic properties, helping to modulate the stress response and maintain homeostasis, particularly during periods of physical or psychological stress.
Dosage and Suggested Use
  • Clinical Dosage Range: Black seed oil doses for cortisol regulation range between 500 mg to 2 g per day, depending on the preparation (oil, powder, or extract). Consistent use over 4-8 weeks appears to be key for seeing benefits.
  • Consultation Recommendation: As with any supplement, individuals should consult with a healthcare provider before adding black seed oil to their regimen, especially when addressing hormonal balance.
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