Thymoquinone > Cardiovascular

Thymoquine & Cardiovascular

Research on thymoquinone, the active compound in black cumin seed oil, has demonstrated significant potential in supporting cardiovascular health. Studies indicate that thymoquinone can improve cardiovascular function, reduce oxidative stress, and positively affect lipid profiles.

Key Findings
  • Overall Cardiovascular Benefits A comprehensive review of the literature examined the potential cardiovascular benefits of Nigella sativa (black cumin) and its active compound, thymoquinone.
  • Cardiometabolic Risk Reduction A randomized controlled trial showed that Nigella sativa (black cumin seed oil), combined with a low-calorie diet, effectively reduced cardiometabolic risk factors in obese women, including improvements in lipid profiles and weight management.
  • Cardiovascular Function and Inflammation: Thymoquinone has been shown to improve cardiovascular function in animals by reducing oxidative stress, inflammation, and apoptosis through the PI3K/Akt pathway. This pathway plays a critical role in cell survival and metabolism.
  • Protection Against Environmental Pollutants: Studies have found that thymoquinone can counteract the harmful effects of diesel exhaust particles on the cardiovascular and pulmonary systems, highlighting its protective capabilities.
  • Blood Pressure, Blood Sugar and Body Weight: A randomized, double-blind controlled trial explored the effects of powdered Nigella sativa (kalonji) seed in capsules on various health markers, including serum lipid levels, blood sugar, blood pressure, and body weight. The study found favorable impacts across these variables, suggesting the potential benefits of Nigella sativa for metabolic health, although larger studies are needed to confirm these findings.
Dosage and Suggested Use

Dosages of Nigella sativa (NS) for cardiovascular benefits can vary depending on the form used (seed, oil, or extract). Clinical trials have utilized a range of dosages:

  • Seed and Powder: Typically used in doses of around 1-3 grams daily.
  • Oil: Commonly used in doses ranging from 500 mg to 2 grams daily.
  • Standardization: It’s important to note that standardized preparations, such as those with 3% thymoquinone, may require smaller doses due to higher potency. Always consult with a healthcare provider to determine the appropriate dosage for individual needs.

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